Manus Ipek

β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action

Jason Xiang, Manus Ipek, Vipin Suri et al. · Bioorganic & Medicinal Chemistry · 2007 · 112 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Aldehyde Dehydrogenase +9

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Yonghan Hu, Jason Xiang, Martin DiGrandi et al. · Bioorganic & Medicinal Chemistry · 2005 · 107 citations

Medicine, Chronic Musculoskeletal Condition, Osteoarthritis +3

Indole Cytosolic Phospholipase A₂α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1<i>H</i>-indol-3-yl]propyl}benzoic Acid, Efipladib

John C. McKew, Katherine L. Lee, Marina W. H. Shen et al. · Journal of Medicinal Chemistry · 2008 · 88 citations

Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

Jason Xiang, Manus Ipek, Vipin Suri et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 84 citations · Full text

Medicinal Chemistry, Biochemistry, 11β-Hydroxysteroid Dehydrogenase Type +8

Efficacious 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors in the Diet-Induced Obesity Mouse Model

Zhao‐Kui Wan, Eva Chenail, Jason Xiang et al. · Journal of Medicinal Chemistry · 2009 · 62 citations · Full text