John C. McKew

Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial

Daniel S. Ory, Elizabeth A. Ottinger, Nicole Y. Farhat et al. · The Lancet · 2017 · 316 citations · Full text

Neurodegenerative Diseases, Neurobiology Of Disease, Clinical Therapeutic +9

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

Jennifer Kouznetsova, Wei Sun, Carles Martínez‐Romero et al. · Emerging Microbes & Infections · 2014 · 240 citations · Full text

Drug Target, Ebola Infection, Medicine +14

Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

Jingsong Cao, Yingjiang Zhou, Haibing Peng et al. · Journal of Biological Chemistry · 2011 · 149 citations · Full text

Small Molecule Inhibitors, Metabolic Diseases, Metabolic Remodeling +18

δ-Tocopherol Reduces Lipid Accumulation in Niemann-Pick Type C1 and Wolman Cholesterol Storage Disorders

Miao Xu, Ke Liu, Manju Swaroop et al. · Journal of Biological Chemistry · 2012 · 123 citations · Full text

Lipid Analysis, Pathology, Cellular Physiology +21

β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action

Jason Xiang, Manus Ipek, Vipin Suri et al. · Bioorganic & Medicinal Chemistry · 2007 · 112 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Aldehyde Dehydrogenase +9