Michael DeGraffenreid

Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3

Zhihong Li, Xianghong Wang, John Eksterowicz et al. · Journal of Medicinal Chemistry · 2014 · 72 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model^▽

Lisa D. Julian, Zhulun Wang, Tracy Bostick et al. · Journal of Medicinal Chemistry · 2008 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors

Hilary P. Beck, Michael DeGraffenreid, Brian M. Fox et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 42 citations

Medicine, Oncology, Pharmacology +14

Distinctive molecular inhibition mechanisms for selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1

Hua Tu, Jay P. Powers, Jinsong Liu et al. · Bioorganic & Medicinal Chemistry · 2008 · 40 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +8

An Efficient and Scalable One-Pot Double Michael Addition-Dieckmann Condensation for the Synthesis of 4,4-Disubstituted Cyclohexane β-Keto Esters

Michael DeGraffenreid, Sarah M. Bennett, Sébastien Caillé et al. · The Journal of Organic Chemistry · 2007 · 27 citations

Natural Sciences, Chemistry, Medicinal Chemistry +13