Concepedia

Author

Jay P. Powers

Amgen (United States)ORCID

Also Known As

J P Powers, J Powers, J. P. POWERS, J. P. Powers, J. Powers, J.P. Powers, J.P.S. Powers, Jay P Powers, Jay P. Powers, Jay Powers

122

Publications

2.8K

Citations

27

H-Index

83

Concepts

All Affiliations

Amgen (United States)ChemoCentryx (United States)Pulse Biosciences (United States)Leipzig University
JP

About

Jay P. Powers is an author at Amgen (United States) specializing in medicine, pharmacology, and drug discovery.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

19

25

1.7K

2

Natural Sciences

13

13

510

3

Engineering

6

6

211

4

Health Sciences

2

2

136

5

Allergy

1

1

144

Jay P. Powers

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42

Publications

2.5K

Citations

27

H-Index

YearCitations

C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN

Hong Xiao, Daniel J. Dairaghi, Jay P. Powers,

Journal of the American Society of Nephrology

2013

346

Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands

Brian A. Zabel, Yu Wang, Susanna Lewén,

The Journal of Immunology

2009

285

Crystal Structures of IRAK-4 Kinase in Complex with Inhibitors: A Serine/Threonine Kinase with Tyrosine as a Gatekeeper

Zhulun Wang, Jinsong Liu, Athena Sudom,

Structure

2006

145

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Pirow Bekker, Daniel J. Dairaghi, Lisa Seitz,

PLoS ONE

2016

144

SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase

Jay P. Powers, Derek E. Piper, Yang Li,

Journal of Medicinal Chemistry

2006

125

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

Jay P. Powers, Shyun Li, Juan C. Jaén,

Bioorganic & Medicinal Chemistry Letters

2006

116

Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats

Matthew J. Walters, Karen Ebsworth, Robert D. Berahovich,

British Journal of Cancer

2014

86

CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

Daniel J. Dairaghi, Babatunde O. Oyajobi, Anjana Gupta,

Blood

2012

86

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice

Timothy J. Sullivan, Zhenhua Miao, Daniel J. Dairaghi,

American Journal of Physiology-Renal Physiology

2013

86

Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors

Felix González-López de Turiso, Daqing Sun, Yosup Rew,

Journal of Medicinal Chemistry

2013

83

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