Highly Enantioselective Hydrogenation of Styrenes Directed by 2′-Hydroxyl Groups

Xiang Wang, Anil S. Guram, Seb Caille, +4

Organic Letters

Styrenes DirectedChemical EngineeringEnantioselective SynthesisEngineeringAlkene Metathesis +10

Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

John G. Allen, Mirna Mujacic, Michael Frohn, +18

ACS Chemical Biology

Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model^▽

Lisa D. Julian, Zhulun Wang, Tracy Bostick, +18

Journal of Medicinal Chemistry

Metabolomic ProfilingPharmacotherapyMetabolic RemodelingPyridyl Compound 13Pharmaceutical Chemistry +16

Multi-Kilo Delivery of AMG 925 Featuring a Buchwald–Hartwig Amination and Processing with Insoluble Synthetic Intermediates

Caroline Affouard, Richard Crockett, Khalid Diker, +4

Organic Process Research & Development

Organic ChemistryChemistryReagentPharmaceutical ChemistryMedicinal Chemistry +16

Diastereoselective Palladium-Catalyzed α-Arylation of 4-Substituted Cyclohexyl Esters

Eric A. Bercot, Seb Caille, Tracy Bostick, +3

Organic Letters

Room TemperatureCross-coupling ReactionEngineering4-Substituted Cyclohexyl EstersOrganic Chemistry +7

Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS^G12C Inhibitor

Liang Zhang, Daniel J. Griffin, Matthew G. Beaver, +38

Organic Process Research & Development

Combinatorial ChemistryMedicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryAmg 510 +10

Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes

James I. Murray, Liang Zhang, Adam C. Simon, +4

Organic Process Research & Development

EngineeringKey Suzuki CouplingMechanical EngineeringOrganic ChemistryChemistry +15

<i>Ipso</i> Nitration of Aryl Boronic Acids Using Fuming Nitric Acid

James I. Murray, Maria Victoria Silva Elipe, Kyle D. Baucom, +3

The Journal of Organic Chemistry

Kinetic Investigations To Enable Development of a Robust Radical Benzylic Bromination for Commercial Manufacturing of AMG 423 Dihydrochloride Hydrate

James I. Murray, Maria Victoria Silva Elipe, Andrew Cosbie, +3

Organic Process Research & Development

Chemical KineticsEngineeringOrganic ChemistrySimple Procedural ChangeChemistry +15

Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

Dustin L. McMinn, Yosup Rew, Athena Sudom, +16

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +8