Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

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Pharmacy, Medicinal Chemistry, Pharmacology +17

Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886

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Life Sciences, Biochemistry, Pharmacology +8

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

Bernard Côté, Louise Boulet, Christine Brideau et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 128 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Microwave promoted synthesis of functionalized 2-aminothiazoles

George W. Kabalka, Arjun R. Mereddy · Tetrahedron Letters · 2006 · 89 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

Microsomal Prostaglandin E₂ Synthase-1 (mPGES-1): A Novel Anti-Inflammatory Therapeutic Target

Richard W. Friesen, Joseph A. Mancini · Journal of Medicinal Chemistry · 2008 · 80 citations · Full text

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