Microsomal Prostaglandin E₂ Synthase-1 (mPGES-1): A Novel Anti-Inflammatory Therapeutic Target

Abstract

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTMicrosomal Prostaglandin E2 Synthase-1 (mPGES-1): A Novel Anti-Inflammatory Therapeutic TargetRichard W. Friesen*† and Joseph A. Mancini‡View Author Information Departments of Medicinal Chemistry and Biochemistry, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec H9H 3L1, Canada* To whom correspondence should be addressed. Phone: (514) 428-3164. Fax: (514) 428-2624. E-mail: [email protected]†Department of Medicinal Chemistry.‡Department of Biochemistry.Cite this: J. Med. Chem. 2008, 51, 14, 4059–4067Publication Date (Web):May 7, 2008Publication History Received25 February 2008Published online7 May 2008Published inissue 1 July 2008https://pubs.acs.org/doi/10.1021/jm800197bhttps://doi.org/10.1021/jm800197breview-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views2170Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Inflammation,Inhibition,Inhibitors,Peptides and proteins,Rodent models Get e-Alerts