Concepedia

Eicosanoid Biosynthesis

Eicosanoid Biosynthesis is the lipid metabolic pathway in which 20-carbon polyunsaturated fatty acids, primarily arachidonic acid, are enzymatically oxygenated by cyclooxygenases, lipoxygenases, and cytochrome P450 monooxygenases to generate bioactive eicosanoid mediators such as prostaglandins, thromboxanes, leukotrienes, and related oxidized derivatives.

14.4K

Publications

830.4K

Citations

41K

Authors

5K

Institutions

Publications per year

2017–2026

1K

Parents

Children

Publications

14.4K

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

, , +10

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

, , +16

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

Arun J. Sanyal, Naga Chalasani, Kris V. Kowdley et al. · New England Journal of Medicine · 2010 · 3.3K citations · Full text

, , +7

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

, , +14

Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis

Mitsuhiro Yokoyama, Hideki Origasa, Masunori Matsuzaki et al. · The Lancet · 2007 · 2.5K citations

, , +12

1–5 of 14.4K

Authors

41K

  1. BS
    Bengt Samuelsson

    Karolinska Institutet, Sweden

    134 publications · 22.9K citations

    80

    h-index

  2. JR
    John R. Falck

    The University of Texas Southwestern Medical Center, United States

    178 publications · 13.1K citations

    68

    h-index

  3. CN
    Charles N. Serhan

    Brigham and Women's Hospital, United States

    71 publications · 12.6K citations

    48

    h-index

  4. DC
    Darryl C. Zeldin

    National Institute of Environmental Health Sciences, United States

    78 publications · 6.8K citations

    47

    h-index

  5. MH
    Mats Hámberg

    Karolinska Institutet, Sweden

    91 publications · 14.1K citations

    46

    h-index

1–5 of 41K

Institutions

5K

  1. Karolinska Institutet

    Stockholm, Sweden

    103 h-index

    1.1K publications

    119.5K citations

  2. Harvard University

    Cambridge, United States

    86 h-index

    807 publications

    114.5K citations

  3. Vanderbilt University

    Nashville, United States

    84 h-index

    910 publications

    89.7K citations

  4. Brigham and Women's Hospital

    Boston, United States

    77 h-index

    574 publications

    102.1K citations

  5. National Institutes of Health

    Bethesda, United States

    68 h-index

    530 publications

    50.2K citations

  6. The University of Texas Southwestern Medical Center

    Dallas, United States

    63 h-index

    490 publications

    38.3K citations

  7. Washington University in St. Louis

    St Louis, United States

    62 h-index

    440 publications

    46.7K citations

  8. University of Michigan

    Ann Arbor, United States

    59 h-index

    412 publications

    40.2K citations

1–8 of 5K

Venues

  1. Journal of Biological Chemistry

    JBC · 748 publications · 88.1K citations

    160

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  2. Proceedings of the National Academy of Sciences

    PNAS · 187 publications · 47.2K citations

    117

    h-index

  3. PubMed

    Repository · 786 publications · 33.5K citations

    83

    h-index

  4. Biochemical and Biophysical Research Communications

    BBRC · 362 publications · 20.8K citations

    81

    h-index

  5. Journal of Clinical Investigation

    JCI · 124 publications · 21.2K citations

    78

    h-index

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