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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

Bernard Côté, Louise Boulet, Christine Brideau, David Claveau, Diane Ethier, Richard Frenette, Marc Gagnon, André Giroux, Jocelyne Guay, Sébastien Guiral,

Bioorganic & Medicinal Chemistry Letters · 2007 · 128 citations · 15 references

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15

Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

Per‐Johan Jakobsson, Staffan Thorén, Ralf Morgenstern et al. · Proceedings of the National Academy of Sciences · 1999 · 995 citations

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Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Makoto Murakami, Hiroaki Naraba, Toshihiro Tanioka et al. · Journal of Biological Chemistry · 2000 · 968 citations · Full text

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Altered pain perception and inflammatory response in mice lacking prostacyclin receptor

Fumitaka Ushikubi, Toshiyuki Matsuoka, Masakazu Hirata et al. · Nature · 1997 · 783 citations

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Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

Catherine E. Trebino, Jeffrey L. Stock, Colleen P. Gibbons et al. · Proceedings of the National Academy of Sciences · 2003 · 547 citations · Full text

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Etoricoxib (MK-0663): Preclinical Profile and Comparison with Other Agents That Selectively Inhibit Cyclooxygenase-2

Denis Riendeau, M. David Percival, Christine Brideau et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 460 citations · Full text

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