Restoring Methicillin-Resistant <i>Staphylococcus aureus</i> Susceptibility to β-Lactam Antibiotics

Christopher M. Tan, Alex G. Therien, Jun Lü, +35

Science Translational Medicine

Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis

Joseph A. Mancini, Katherine A Blood, Jocelyne Guay, +4

Journal of Biological Chemistry

Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

David Claveau, Mirna Sirinyan, Jocelyne Guay, +5

The Journal of Immunology

InflammationRheumatologyRheumatoid DisorderAnti-inflammatoryAutoimmune Disease +11

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

Bernard Côté, Louise Boulet, Christine Brideau, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +9

Inhibition of Cathepsin K by Nitric Oxide Donors:  Evidence for the Formation of Mixed Disulfides and a Sulfenic Acid

M. David Percival, Marc Ouellet, Christine Campagnolo, +2

Biochemistry

SclerostinChemical BiologyOsteoporosisRedox BiologyOxidative Stress +15

Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor

David Claveau, S L Chen, Stephen J. O’Keefe, +6

Journal of Pharmacology and Experimental Therapeutics

Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

Alex G. Therien, Joann Huber, Kenneth E. Wilson, +30

Antimicrobial Agents and Chemotherapy

Spsb InhibitorsAntimicrobial ChemotherapyBacterial PathogensDrug ResistanceAntibacterial Mechanisms +19

Pyridazinones as selective cyclooxygenase-2 inhibitors

Chun Sing Li, Christine Brideau, Chi Chung Chan, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacological Agent +6

Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors

André Giroux, Louise Boulet, Christine Brideau, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDisubstituted Phenanthrene ImidazolesBiochemistryMedicineNatural Sciences +9

Preparation of nano-CaO using thermal-decomposition method

Zhen‐Xing Tang, David Claveau, R. Corcuff, +2

Materials Letters

Materials ScienceMaterials EngineeringEngineeringThermal-decomposition MethodCalcium Aluminate +5