André Giroux

Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury

Byung Hee Han, Daigen Xu, Junjeong Choi et al. · Journal of Biological Chemistry · 2002 · 177 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

MF63 [2-(6-Chloro-1 H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

Daigen Xu, Steven E. Rowland, Patsy Clark et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 152 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Enzymatic preparation of biosurfactants from sugars or sugar alcohols and fatty acids in organic media under reduced pressure

Amélie Ducret, André Giroux, Michael Trani et al. · Biotechnology and Bioengineering · 1995 · 131 citations

Life Sciences, Biochemistry, Biotechnology +11

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

Bernard Côté, Louise Boulet, Christine Brideau et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 128 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors

Paul Tawa, Kai Hell, André Giroux et al. · Cell Death and Differentiation · 2004 · 122 citations

Life Sciences, Biochemistry, Chemistry +12