Christopher Hulme

New 4-Point Pharmacophore Method for Molecular Similarity and Diversity Applications:  Overview of the Method and Applications, Including a Novel Approach to the Design of Combinatorial Libraries Containing Privileged Substructures

Jonathan Mason, Isabelle Morize, Paul R. Menard et al. · Journal of Medicinal Chemistry · 1999 · 376 citations · Full text

Drug Target, Novel Approach, Molecular Biology +19

Health Outcome Measures in the Evaluation of Total Hip Arthroplasties—A Comparison Between the Harris Hip Score and the Oxford Hip Score

Yegappan Kalairajah, Koldo Azurza, Christopher Hulme et al. · The Journal of Arthroplasty · 2005 · 222 citations

Harris Hip Score, Hip Arthroplasty, Health Outcome Measures +10

The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: A structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796

Justin Dietrich, Christopher Hulme, Laurence H. Hurley · Bioorganic & Medicinal Chemistry · 2010 · 179 citations · Full text

Drug Target, Engineering, Biochemistry +8

Hypervalent Iodine Chemistry:  New Oxidation Reactions Using the Iodosylbenzene−Trimethylsilyl Azide Reagent Combination. Direct α- and β-Azido Functionalization of Triisopropylsilyl Enol Ethers

Philip Magnus, Jérôme Lacour, P. Andrew Evans et al. · Journal of the American Chemical Society · 1996 · 155 citations

Triisopropylsilyl Enol Ethers, Phio/tmsn3/at −18, Engineering +16

Dyrk1 inhibition improves Alzheimer's disease‐like pathology

Caterina Branca, Darren M. Shaw, Ramona Belfiore et al. · Aging Cell · 2017 · 123 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +13