Laurence H. Hurley

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- <i>MYC</i> transcription

Adam Siddiqui-Jain, Cory L. Grand, David J. Bearss et al. · Proceedings of the National Academy of Sciences · 2002 · 2.2K citations

Life Sciences, Genetics, Molecular Biology +17

Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Daekyu Sun, Brian Thompson, Brian E. Cathers et al. · Journal of Medicinal Chemistry · 1997 · 784 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +11

Telomestatin, a Potent Telomerase Inhibitor That Interacts Quite Specifically with the Human Telomeric Intramolecular G-Quadruplex

Mu-Yong Kim, Hariprasad Vankayalapati, Kazuo Shin‐ya et al. · Journal of the American Chemical Society · 2002 · 515 citations

Life Sciences, Biochemistry, Molecular Biology +17

Cationic Porphyrins as Telomerase Inhibitors:  the Interaction of Tetra-(<i>N</i>-methyl-4-pyridyl)porphine with Quadruplex DNA

Richard T. Wheelhouse, Daekyu Sun, Haiyong Han et al. · Journal of the American Chemical Society · 1998 · 446 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +12

Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the <i>bcl-2</i> P1 Promoter

Thomas S. Dexheimer, Daekyu Sun, Laurence H. Hurley · Journal of the American Chemical Society · 2006 · 391 citations · Full text

Life Sciences, Genetics, Molecular Biology +15