Brian E. Cathers

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Jan Krönke, Emma C. Fink, Paul W. Hollenbach et al. · Nature · 2015 · 816 citations · Full text

Medicine, Cell Death, Pharmacology +2

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Antonia Lopez‐Girona, Derek Mendy, Takumi Ito et al. · Leukemia · 2012 · 783 citations · Full text

Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Daekyu Sun, Brian Thompson, Brian E. Cathers et al. · Journal of Medicinal Chemistry · 1997 · 780 citations · Full text

Engineering, Altmetric Attention Score, Molecular Biology +19

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Mary E. Matyskiela, Gang Lu, Takumi Ito et al. · Nature · 2016 · 628 citations

Protein Function, Signal Transduction, Cell Regulation +10

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Philip P. Chamberlain, Antonia Lopez‐Girona, Karen Miller et al. · Nature Structural & Molecular Biology · 2014 · 499 citations

Molecular Pharmacology, Natural Sciences, Molecular Biology +6