Concepedia

Takumi Ito

TI

40

Publications

5.9K

Citations

22

H-Index

1967

Active since

Affiliations

Tokyo Institute of Technology(Current)

Tokyo Medical University

Japan Science and Technology Agency

Chiba University

Osaka Medical and Pharmaceutical University

Takumi Ito is an author at Tokyo Institute of Technology specializing in medicine, engineering, and molecular biology.

ORCID

Top concepts

Publications per year

1967–2021

40

Publications

40

Identification of a Primary Target of Thalidomide Teratogenicity

Takumi Ito, Hideki Ando, Takayuki Suzuki et al. · Science · 2010 · 2K citations

, , +14

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Antonia Lopez‐Girona, Derek Mendy, Takumi Ito et al. · Leukemia · 2012 · 783 citations · Full text

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Mary E. Matyskiela, Gang Lu, Takumi Ito et al. · Nature · 2016 · 628 citations

, , +10

Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate <scp>T</scp> cells by inducing degradation of <scp>T</scp> cell repressors <scp>I</scp> karos and <scp>A</scp> iolos via modulation of the <scp>E</scp> 3 ubiquitin ligase complex <scp>CRL</scp> 4 <scp> <sup>CRBN</sup> </scp>

Anita K. Gandhi, Jian Kang, Courtney G. Havens et al. · British Journal of Haematology · 2013 · 611 citations · Full text

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Philip P. Chamberlain, Antonia Lopez‐Girona, Karen Miller et al. · Nature Structural & Molecular Biology · 2014 · 499 citations

, , +6

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