Concepedia

Author

Takumi Ito

Tokyo Institute of TechnologyORCID

Also Known As

Ito, Takayuki, T Ito, T. Ito, Takayuki Ito, Takumi ITO, Takumi Ito

123

Publications

6.8K

Citations

29

H-Index

90

Concepts

All Affiliations

Tokyo Institute of TechnologyTokyo Medical UniversityJapan Science and Technology AgencyChiba UniversityOsaka Medical and Pharmaceutical University
TI

About

Takumi Ito is an author at Tokyo Institute of Technology specializing in medicine, engineering, and molecular biology.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

13

14

3.7K

2

Engineering

5

5

120

3

Natural Sciences

4

4

1.2K

4

Social Sciences

3

3

74

5

Health Sciences

1

1

13

Takumi Ito

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40

Publications

5.9K

Citations

22

H-Index

YearCitations

Identification of a Primary Target of Thalidomide Teratogenicity

Takumi Ito, Hideki Ando, Takayuki Suzuki,

Science

2010

2K

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Antonia Lopez‐Girona, Derek Mendy, Takumi Ito,

Leukemia

2012

783

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Mary E. Matyskiela, Gang Lu, Takumi Ito,

Nature

2016

628

Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate <scp>T</scp> cells by inducing degradation of <scp>T</scp> cell repressors <scp>I</scp> karos and <scp>A</scp> iolos via modulation of the <scp>E</scp> 3 ubiquitin ligase complex <scp>CRL</scp> 4 <scp> <sup>CRBN</sup> </scp>

Anita K. Gandhi, Jian Kang, Courtney G. Havens,

British Journal of Haematology

2013

611

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Philip P. Chamberlain, Antonia Lopez‐Girona, Karen Miller,

Nature Structural & Molecular Biology

2014

499

p63 is a cereblon substrate involved in thalidomide teratogenicity

Tomoko Asatsuma‐Okumura, Hideki Ando, Marco De Simone,

Nature Chemical Biology

2019

134

Structural basis of thalidomide enantiomer binding to cereblon

Tomoyuki Mori, Takumi Ito, Shujie Liu,

Scientific Reports

2018

119

Molecular mechanisms of thalidomide and its derivatives

Takumi Ito, Hiroshi Handa

Proceedings of the Japan Academy Series B

2020

108

Constructing oscillation preventing scheme for advection equation by rational function

Feng Xiao, Takumi Ito

Computer Physics Communications

1996

106

ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells

Junichi Yamamoto, Tetsufumi Suwa, Yuki Murase,

Nature Chemical Biology

2020

95

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