The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

Yupeng He, Sujatha Selvaraju, Michael L. Curtin, +34

Nature Chemical Biology

Protein FunctionSignal TransductionMolecular RegulationPrc2 ComplexMolecular Biology +5

The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: A structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796

Justin Dietrich, Christopher Hulme, Laurence H. Hurley

Bioorganic & Medicinal Chemistry

Drug TargetEngineeringBiochemistryMedicinePharmacology +6

Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water

Desislava Petkova, Niginia Borlinghaus, Sudripet Sharma, +10

ACS Sustainable Chemistry & Engineering

EngineeringHpmc EnableSuper-hydrophobic SurfaceChemistryProtein Nanoparticles +17

Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells

Breland E. Smith, Hui Hua Chang, Federico Medda, +5

Bioorganic & Medicinal Chemistry Letters

Biological ActivityPge2 ProductionBiochemistryNatural SciencesMedicine +6

Discovery of a Ni2+-dependent guanidine hydrolase in bacteria

Dietmar Funck, Malte Sinn, Jennifer R. Fleming, +5

Nature

BiochemistryReactive Nitrogen SpecieEnvironmental MicrobiologyMicrobiologyNi2+-dependent Guanidine Hydrolase +1

A simple, cheap alternative to ‘designer convertible isonitriles’ expedited with microwaves

Christopher Hulme, Shashi Chappeta, Justin Dietrich

Tetrahedron Letters

Materials ScienceEngineeringMicrofabricationMaterials FabricationMechanical Engineering +4

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma

Yael Kusne, Eugenio Antonio Carrera Silva, Anthony S. Perry, +14

Science Signaling

Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors

Justin Dietrich, Vijay Gokhale, Xiaodong Wang, +2

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesSubstituted Imidazoles +5

An efficient solution phase synthesis of triazadibenzoazulenones: ‘designer isonitrile free’ methodology enabled by microwaves

Christopher Hulme, Shashi Chappeta, Chris Griffith, +2

Tetrahedron Letters

Materials ScienceEngineeringOrganic ChemistrySynthesis MethodChemistry +1

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Justin Dietrich, Kenton L. Longenecker, Noel S. Wilson, +26

Journal of Medicinal Chemistry