The Dynamic Character of the G-Quadruplex Element in the c-MYC Promoter and Modification by TMPyP4

Jeyaprakashnarayanan Seenisamy, Evonne M. Rezler, Tiffanie J. Powell, +5

Journal of the American Chemical Society

Molecular RegulationG-quadruplex ElementMolecular BiologyC-myc PromoterTranscriptional Regulation +14

Design and Synthesis of an Expanded Porphyrin That Has Selectivity for the c-MYC G-Quadruplex Structure

Jeyaprakashnarayanan Seenisamy, Bashyam Sridevi, Vijay Gokhale, +8

Journal of the American Chemical Society

Combinatorial ChemistryCationic PorphyrinsMolecular BiologyOrganic ChemistryC-myc Promoter +17

The Dynamic Character of the <i>BCL2</i> Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure

Samantha Kendrick, Hyun-Jin Kang, Mohammad P. Alam, +6

Journal of the American Chemical Society

GeneticsMolecular BiologyMolecular GeneticsGene Regulatory NetworkFlexible Hairpin Species +15

Formation of Pseudosymmetrical G-Quadruplex and i-Motif Structures in the Proximal Promoter Region of the <i>RET</i> Oncogene

Kexiao Guo, Alan Pourpak, Kara Beetz-Rogers, +3

Journal of the American Chemical Society

Ret Basal TranscriptionMolecular BiologyProximal Promoter RegionMolecular GeneticsSequence Motif +17

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex–interactive agents

Daekyu Sun, Weijun Liu, Kexiao Guo, +4

Molecular Cancer Therapeutics

Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4

Yong Qin, Evonne M. Rezler, Vijay Gokhale, +2

Nucleic Acids Research

ChromatinDimethyl SulfateBiochemistryNatural SciencesPdgf-a Promoter Activity +13

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

Kun Guo, Vijay Gokhale, Laurence H. Hurley, +1

Nucleic Acids Research

Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex

Robert V. Brown, Forest Danford, Vijay Gokhale, +2

Journal of Biological Chemistry

Non-hodgkins LymphomaImmunologyDrug-targeted Down-regulationMolecular BiologyNear Upstream Promoter +15

Dyrk1 inhibition improves Alzheimer's disease‐like pathology

Caterina Branca, Darren M. Shaw, Ramona Belfiore, +9

Aging Cell

Neurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseDyrk1 InhibitionMedicine +11

Anticancer Activity and Cellular Repression of c-MYC by the G-Quadruplex-Stabilizing 11-Piperazinylquindoline Is Not Dependent on Direct Targeting of the G-Quadruplex in the c-MYC Promoter

Peda V. L. Boddupally, Seongmin Hahn, Cristina Beman, +4

Journal of Medicinal Chemistry