Concepedia

Proteolytic Stability Control

Proteolytic Stability Control is a methodological construct in protein science that enables the regulation of protein degradation dynamics by selectively modulating susceptibility to proteolytic cleavage through intrinsic structural stabilization or extrinsic inhibitory mechanisms.

487

Publications

33.5K

Citations

2.5K

Authors

712

Institutions

Publications per year

2017–2026

157

Parents

Publications

487

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd, Andrea Testa, Xavier Lucas et al. · Nature Chemical Biology · 2017 · 1.2K citations · Full text

, , +13

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

Daniel P. Bondeson, Blake E. Smith, George M. Burslem et al. · Cell chemical biology · 2017 · 901 citations · Full text

, , +13

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

F.‐Nora Vögtle, Stefanie Wortelkamp, René P. Zahedi et al. · Cell · 2009 · 565 citations · Full text

, , +11

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.

Claude M. Wischik, Patricia C. Edwards, Robert Lai et al. · Proceedings of the National Academy of Sciences · 1996 · 541 citations

, , +17

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

Jörg Gsponer, Matthias E. Futschik, Sarah A. Teichmann et al. · Science · 2008 · 485 citations · Full text

, , +17

1–5 of 487

Authors

2.5K

  1. RT
    Robert T. Sauer

    Massachusetts Institute of Technology, United States

    12 publications · 1.1K citations

    12

    h-index

  2. TA
    Tania A. Baker

    Massachusetts Institute of Technology, United States

    8 publications · 765 citations

    8

    h-index

  3. RH
    Regine Hengge‐Aronis

    University of Konstanz, Germany

    5 publications · 593 citations

    5

    h-index

  4. YA
    Yoshinori Akiyama

    Kyoto University, Japan

    5 publications · 542 citations

    5

    h-index

  5. SG
    Susan Gottesman

    National Cancer Institute, United States

    5 publications · 690 citations

    5

    h-index

1–5 of 2.5K

Institutions

712

  1. Massachusetts Institute of Technology

    Cambridge, United States

    15 h-index

    59 publications

    5.3K citations

  2. Kyoto University

    Kyoto, Japan

    12 h-index

    34 publications

    3.1K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    51 publications

    2.1K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    12 h-index

    31 publications

    4.7K citations

  5. Harvard University

    Cambridge, United States

    10 h-index

    52 publications

    4.5K citations

  6. National Cancer Institute

    Bethesda, United States

    10 h-index

    32 publications

    5.2K citations

  7. Freie Universität Berlin

    Berlin, Germany

    9 h-index

    22 publications

    1.6K citations

  8. University of Pittsburgh

    Pittsburgh, United States

    8 h-index

    24 publications

    1.5K citations

1–8 of 712

Venues

  1. Journal of Biological Chemistry

    JBC · 41 publications · 2.3K citations

    30

    h-index

  2. Molecular Microbiology

    18 publications · 1.3K citations

    17

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 2.4K citations

    15

    h-index

  4. Journal of Medicinal Chemistry

    17 publications · 607 citations

    15

    h-index

  5. Journal of the American Chemical Society

    JACS · 14 publications · 1.3K citations

    14

    h-index

1–5