Claude M. Wischik

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

Michel Goedert, Claude M. Wischik, R. Anthony Crowther et al. · Proceedings of the National Academy of Sciences · 1988 · 1.1K citations · Full text

Molecular Biology, Cytoskeleton, Microtubule-associated Protein Tau +16

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Claude M. Wischik, M Novák, Hans C. Thøgersen et al. · Proceedings of the National Academy of Sciences · 1988 · 940 citations · Full text

Molecular Biology, Alzheimer's Disease, Protein Folding +18

Structural characterization of the core of the paired helical filament of Alzheimer disease.

Claude M. Wischik, M Novák, Patricia C. Edwards et al. · Proceedings of the National Academy of Sciences · 1988 · 590 citations · Full text

Structural Characterization, Molecular Biology, Cytoskeleton +19

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.

Claude M. Wischik, Patricia C. Edwards, Robert Lai et al. · Proceedings of the National Academy of Sciences · 1996 · 532 citations · Full text

Protein Assembly, Molecular Biology, Neurochemical Biomarkers +18

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

Serge Gauthier, Howard Feldman, Lon S. Schneider et al. · The Lancet · 2016 · 405 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Pharmacology +10