George M. Burslem

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

Daniel P. Bondeson, Blake E. Smith, George M. Burslem et al. · Cell chemical biology · 2017 · 901 citations · Full text

Engineering, Bioengineering, Biomolecular Engineering +13

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

George M. Burslem, Blake E. Smith, Ashton C. Lai et al. · Cell chemical biology · 2017 · 673 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation

George M. Burslem, Anna Reister Schultz, Daniel P. Bondeson et al. · Cancer Research · 2019 · 222 citations

Medicine, Molecular Biology, Oncology +14

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

George M. Burslem, Jayoung Song, Xin Chen et al. · Journal of the American Chemical Society · 2018 · 175 citations

Medicine, Oncology, Pharmacology +13

Double quick, double click reversible peptide “stapling”

Claire M. Grison, George M. Burslem, Jennifer A. Miles et al. · Chemical Science · 2017 · 102 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +14