George M. Burslem

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

Daniel P. Bondeson, Blake E. Smith, George M. Burslem et al. · Cell chemical biology · 2017 · 867 citations · Full text

Protac Design, Selective Degradation, Biomolecular Engineering +1

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

George M. Burslem, Blake E. Smith, Ashton C. Lai et al. · Cell chemical biology · 2017 · 643 citations · Full text

Protein Chemistry, Protein Function, Biochemistry +14

Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation

George M. Burslem, Anna Reister Schultz, Daniel P. Bondeson et al. · Cancer Research · 2019 · 213 citations

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

George M. Burslem, Jayoung Song, Xin Chen et al. · Journal of the American Chemical Society · 2018 · 168 citations

Chemical Biology, Pharmaceutical Chemistry, Tumor Biology +19

Double quick, double click reversible peptide “stapling”

Claire M. Grison, George M. Burslem, Jennifer A. Miles et al. · Chemical Science · 2017 · 101 citations · Full text