Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

George M. Burslem, Jayoung Song, Xin Chen, +2

Journal of the American Chemical Society

Chemical BiologyPharmaceutical ChemistryTumor BiologyMedicinal ChemistryReceptor Tyrosine Kinase +17

Catalytic and Enantioselective Control of the C–N Stereogenic Axis via the Pictet–Spengler Reaction

Ahreum Kim, Aram Kim, Sunjung Park, +6

Angewandte Chemie International Edition

Bioorganic ChemistryEngineeringOrganic ChemistryChemistryChemical Engineering +16

Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents

Yongseok Kwon, Jayoung Song, Hong‐Gu Lee, +4

Journal of Medicinal Chemistry

Biological ActivityCompound 5BMedicinal ChemistryPharmaceutical ScienceNatural Alkaloids +13

Stereoselective Synthesis of 4′-Selenonucleosides via Seleno-Michael Reaction as Potent Antiviral Agents

Gyudong Kim, Jinha Yu, Ji Yoon Ahn, +7

Organic Letters

Viral ReplicationBioorganic ChemistrySynthetic VirologyMolecular BiologyOrganic Chemistry +15

Anti-proliferative activity and suppression of P-glycoprotein by (−)-antofine, a natural phenanthroindolizidine alkaloid, in paclitaxel-resistant human lung cancer cells

Eunhye Kim, Hye‐Young Min, Hwa‐Jin Chung, +4

Food and Chemical Toxicology

Molecular PharmacologyAnti-proliferative ActivityBiochemistryMedicinePulmonary Pharmacology +6

Structure–Activity Relationships of Neplanocin A Analogues as <i>S</i>-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities

Girish Chandra, Yang Won Moon, Yoonji Lee, +12

Journal of Medicinal Chemistry

Peptide ScienceChemical BiologyStructure–activity RelationshipsPharmaceutical ChemistryMolecular Pharmacology +18

Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation

Mark Borris D. Aldonza, Ji‐Young Hong, Malona V. Alinsug, +2

Oncotarget

Tumor BiologyFoxo3a-mediated Abcb1 RegulationHealth SciencesMedicineCancer Cell Biology +13

A novel selenonucleoside suppresses tumor growth by targeting Skp2 degradation in paclitaxel-resistant prostate cancer

Woong Sub Byun, Minkyung Jin, Jinha Yu, +5

Biochemical Pharmacology

Paclitaxel-resistant Prostate CancerSkp2 DegradationMedicinePharmacologyCancer Biology +7

Antitumor Activity of Phenanthroindolizidine Alkaloids Is Associated with Negative Regulation of Met Endosomal Signaling in Renal Cancer Cells

Jayoung Song, Yongseok Kwon, Sanghee Kim, +1

Chemistry & Biology

Tumor BiologyAntitumor ActivityOncogenic AgentMedicinePharmacology +7

Suppression of MAPK Signaling and Reversal of mTOR-Dependent MDR1-Associated Multidrug Resistance by 21α-Methylmelianodiol in Lung Cancer Cells

Mark Borris D. Aldonza, Ji‐Young Hong, Song Yi Bae, +6

PLoS ONE

Tumor BiologyMedicineCancer Cell BiologyCell DeathNsclc Cells +11