Concepedia

Protein-excipient Interactions

Protein-Excipient Interactions is a theoretical construct in pharmaceutical biophysics that characterizes the molecular-level associative forces and stabilization mechanisms between proteins and excipients during lyophilization, distinguishing it from other formulation phenomena by its focus on preserving protein conformational integrity through specific physicochemical interactions.

85

Publications

3.5K

Citations

339

Authors

123

Institutions

Publications per year

2017–2026

41

Parents

Publications

85

Tunable and reversible drug control of protein production via a self-excising degron

H. Kay Chung, C. Jacobs, Yunwen Huo et al. · Nature Chemical Biology · 2015 · 240 citations · Full text

, , +12

Impact of non-covalent bound polyphenols on conformational, functional properties and in vitro digestibility of pea protein

Linlin Hao, Jinwei Sun, Mengqi Pei et al. · Food Chemistry · 2022 · 215 citations

, , +16

Amino acids as co-amorphous stabilizers for poorly water-soluble drugs – Part 2: Molecular interactions

Korbinian Löbmann, Riikka Laitinen, Clare J. Strachan et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2013 · 191 citations

, , +16

Enhancement of the solubility, stability and bioaccessibility of quercetin using protein-based excipient emulsions

Xing Chen, David Julian McClements, Yuqing Zhu et al. · Food Research International · 2018 · 151 citations

, , +12

Effect of Excipients on the Stability and Structure of Lyophilized Recombinant Human Growth Hormone

Henry R. Costantino, Karen G. Carrasquillo, Rocio A. Cordero et al. · Journal of Pharmaceutical Sciences · 1998 · 144 citations

, , +11

1–5 of 85

Authors

339

  1. HG
    Holger Grohganz

    University of Copenhagen, Denmark

    4 publications · 253 citations

    4

    h-index

  2. EM
    Elizabeth M. Topp

    University of Kansas, United States

    4 publications · 153 citations

    4

    h-index

  3. HA
    Hasige A. Sathish

    Massachusetts Institute of Technology, United States

    3 publications · 124 citations

    3

    h-index

  4. AM
    Alexander M. Klibanov

    Massachusetts Institute of Technology, United States

    3 publications · 288 citations

    3

    h-index

  5. JR
    Jukka Rantanen

    University of Copenhagen, Denmark

    3 publications · 62 citations

    3

    h-index

1–5 of 339

Institutions

123

  1. University of Copenhagen

    Copenhagen, Denmark

    7 h-index

    26 publications

    997 citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    6 h-index

    23 publications

    1.6K citations

  3. University of Kansas

    Lawrence, United States

    5 h-index

    19 publications

    676 citations

  4. Ludwig-Maximilians-Universität München

    Munich, Germany

    3 h-index

    5 publications

    106 citations

  5. University of Colorado Denver

    Denver, United States

    3 h-index

    8 publications

    365 citations

  6. State Key Laboratory of Food Science and Technology

    Wuxi, China

    3 h-index

    21 publications

    1.7K citations

  7. Nanchang University

    Nanchang, China

    3 h-index

    21 publications

    1.7K citations

  8. University of Massachusetts Amherst

    Amherst Center, United States

    3 h-index

    3 publications

    227 citations

1–8 of 123

Venues

  1. Pharmaceutical Research

    11 publications · 449 citations

    11

    h-index

  2. Molecular Pharmaceutics

    10 publications · 338 citations

    11

    h-index

  3. Journal of Pharmaceutical Sciences

    10 publications · 527 citations

    10

    h-index

  4. International Journal of Pharmaceutics

    7 publications · 210 citations

    7

    h-index

  5. European Journal of Pharmaceutics and Biopharmaceutics

    EJPB · 4 publications · 254 citations

    4

    h-index

1–5