Concepedia

Metabolic Checkpoints

Metabolic Checkpoints is a regulatory construct in immune cell metabolism that denotes specific biochemical nodes where metabolic pathways are selectively controlled to determine immune cell fate, function, and activation thresholds.

72

Publications

14.3K

Citations

823

Authors

280

Institutions

Publications per year

2017–2026

51

Parents

Publications

72

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Dana M. Gwinn, David B. Shackelford, Daniel F. Egan et al. · Molecular Cell · 2008 · 3.8K citations · Full text

, , +15

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Lewis Z. Shi, Ruoning Wang, Gonghua Huang et al. · The Journal of Experimental Medicine · 2011 · 1.8K citations · Full text

, , +17

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ping‐Chih Ho, Jessica Bihuniak, Andrew N. Macintyre et al. · Cell · 2015 · 1.4K citations · Full text

, , +14

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Robert D. Leone, Liang Zhao, Judson M. Englert et al. · Science · 2019 · 1.2K citations

, , +17

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

Antoine Marçais, Julien Cherfils‐Vicini, Charlotte Viant et al. · Nature Immunology · 2014 · 602 citations · Full text

, , +13

1–5 of 72

Authors

823

  1. JC
    Jeffrey C. Rathmell

    Vanderbilt University Medical Center, United States

    3 publications · 1.7K citations

    3

    h-index

  2. AM
    Alanna M. Cameron

    Max Planck Institute of Immunobiology and Epigenetics, Germany

    3 publications · 651 citations

    3

    h-index

  3. EL
    Erika L. Pearce

    Max Planck Institute of Immunobiology and Epigenetics, Germany

    3 publications · 734 citations

    3

    h-index

  4. JA
    Javier A. Menéndez

    Institut Català d'Oncologia, Spain

    2 publications · 156 citations

    2

    h-index

  5. JG
    James G. Vaughn

    University of Oklahoma, United States

    2 publications · 74 citations

    2

    h-index

1–5 of 823

Institutions

280

  1. Sun Yat-sen University

    Guangzhou, China

    6 h-index

    42 publications

    1.6K citations

  2. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    25 publications

    1.5K citations

  3. University of Iowa

    Iowa City, United States

    4 h-index

    11 publications

    2.2K citations

  4. Yale University

    New Haven, United States

    3 h-index

    14 publications

    19.9K citations

  5. Chinese Academy of Medical Sciences & Peking Union Medical College

    Beijing, China

    3 h-index

    22 publications

    913 citations

  6. Inserm

    Paris, France

    3 h-index

    23 publications

    7.4K citations

  7. Sun Yat-sen University Cancer Center

    Guangzhou, China

    3 h-index

    17 publications

    747 citations

  8. Boston University

    Boston, United States

    3 h-index

    12 publications

    1.6K citations

1–8 of 280

Venues

  1. Nature Communications

    5 publications · 553 citations

    5

    h-index

  2. Nature Immunology

    5 publications · 1.6K citations

    5

    h-index

  3. Journal of Clinical Investigation

    JCI · 3 publications · 111 citations

    3

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 254 citations

    3

    h-index

  5. Frontiers in Immunology

    3 publications · 131 citations

    3

    h-index

1–5