Robert D. Leone

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Robert D. Leone, Liang Zhao, Judson M. Englert et al. · Science · 2019 · 1.2K citations

Medicine, Immunology, Oncology +17

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

Reshma Rangwala, Robert D. Leone, Yunyoung C Chang et al. · Autophagy · 2014 · 365 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Liposome-encapsulated vincristine, vinblastine and vinorelbine: A comparative study of drug loading and retention

Igor V. Zhigaltsev, Norbert Maurer, Quet-Fah Akhong et al. · Journal of Controlled Release · 2005 · 187 citations

Pharmacy, Pharmaceutics, Pharmacology +16

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models

Robert D. Leone, Im-Meng Sun, Min Hee Oh et al. · Cancer Immunology Immunotherapy · 2018 · 186 citations · Full text

Medicine, Immunology, Pharmacology +17

Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug

Rana Rais, Kathryn M. Lemberg, Lukáš Tenora et al. · Science Advances · 2022 · 124 citations · Full text

Medicine, Oncology, Pharmacology +17