AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Ken Inoki, Tianqing Zhu, Kun‐Liang Guan · Cell · 2003 · 3.8K citations · Full text

Signal Transduction, Control Cell Growth, Cell Division +10

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw, Katja Lamia, Debbie S. Vasquez et al. · Science · 2005 · 1.9K citations

Ampk Activity, Therapeutic Effects, Metabolic Remodeling +21

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Reuben J. Shaw, Monica Kosmatka, Nabeel Bardeesy et al. · Proceedings of the National Academy of Sciences · 2004 · 1.7K citations · Full text

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

Akseli Hemminki, David Markie, Ian Tomlinson et al. · Nature · 1998 · 1.6K citations

Genetic Disorder, Medicine, Genetics +4

The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

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Biochemistry, Natural Sciences, Peptide Library +6