HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Lewis Z. Shi, Ruoning Wang, Gonghua Huang, +4

The Journal of Experimental Medicine

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

Christopher Lupfer, Paul G. Thomas, Paras Anand, +13

Nature Immunology

InflammationHost ResponseProtein Kinase 2–MediatedVirus InfectionInflammasome Activation +10

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

Guangwei Liu, Samir Burns, Gonghua Huang, +4

Nature Immunology

Receptor S1p1T-regulatory CellImmunologyImmune RegulationCd4 T Cell Responses +14

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

Gonghua Huang, Yanyan Wang, Peter Vogel, +3

Nature Immunology

InflammationAutoimmune InflammationAutoimmune DiseaseImmunologyImmunologic Mechanism +9

Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection

Yang Li, Xiaomin Guo, Chunmiao Hu, +10

Cell Death and Differentiation

Medical MicrobiologyAntimicrobial SusceptibilityHealth SciencesAntibioticsPathogenesis +8

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells

Yanyan Wang, Gonghua Huang, Hu Zeng, +3

Proceedings of the National Academy of Sciences

Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells

Yang Luo, Youqiu Xue, Julie Wang, +5

Cell Reports

Sodium ChlorideLymphocyte DevelopmentT-regulatory CellImmunologyImmune Regulation +22

The Identification of Lymphocyte-Like Cells and Lymphoid-Related Genes in Amphioxus Indicates the Twilight for the Emergency of Adaptive Immune System

Gonghua Huang, Xiaojin Xie, Yan Han, +10

PLoS ONE

Microbial PathogensAdaptive Immune SystemLymphocyte-like CellsImmunologyInnate Immune System +18

Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function

Yanyan Wang, Gonghua Huang, Peter Vogel, +3

Proceedings of the National Academy of Sciences

Signaling by the Phosphatase MKP-1 in Dendritic Cells Imprints Distinct Effector and Regulatory T Cell Fates

Gonghua Huang, Yanyan Wang, Lewis Z. Shi, +2

Immunity

Signal TransductionSignaling PathwayCell RegulationReceptor Tyrosine KinasePhosphatase Mkp-1 +6