Concepedia

Dna Cleavage

DNA cleavage is a biochemical process in which phosphodiester bonds within the DNA backbone are selectively broken by site-specific recombinases, initiating recombination events at defined genomic loci.

3.5K

Publications

247.6K

Citations

11.8K

Authors

2.3K

Institutions

Publications per year

2017–2026

534

Parents

Publications

3.5K

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text

, , +17

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees et al. · Nature · 2017 · 4.2K citations · Full text

, , +12

Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

Giedrius Gasiūnas, Rodolphe Barrangou, Philippe Horvath et al. · Proceedings of the National Academy of Sciences · 2012 · 2.8K citations · Full text

, , +14

Rationally engineered Cas9 nucleases with improved specificity

Ian M. Slaymaker, Linyi Gao, Bernd Zetsche et al. · Science · 2015 · 2.5K citations

, , +15

RNA-programmed genome editing in human cells

Martin Jínek, Alexandra East, Aaron Cheng et al. · eLife · 2013 · 2.2K citations · Full text

, , +15

1–5 of 3.5K

Authors

11.8K

  1. NO
    Neil Osheroff

    Vanderbilt University, United States

    81 publications · 5.2K citations

    46

    h-index

  2. P
    Yves Pommier

    National Cancer Institute, United States

    66 publications · 5K citations

    45

    h-index

  3. AR
    Akhil R. Chakravarty

    Indian Institute of Science Bangalore, India

    39 publications · 2.8K citations

    32

    h-index

  4. SM
    Sidney M. Hecht

    University of Virginia, United States

    43 publications · 1.9K citations

    28

    h-index

  5. GC
    Giovanni Capranico

    Fondazione IRCCS Istituto Nazionale dei Tumori, Italy

    27 publications · 1.8K citations

    24

    h-index

1–5 of 11.8K

Institutions

2.3K

  1. National Institutes of Health

    Bethesda, United States

    47 h-index

    261 publications

    22.9K citations

  2. Vanderbilt University

    Nashville, United States

    46 h-index

    284 publications

    17.7K citations

  3. National Cancer Institute

    Bethesda, United States

    45 h-index

    268 publications

    22.1K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    44 h-index

    454 publications

    24.4K citations

  5. Indian Institute of Science Bangalore

    Bengaluru, India

    40 h-index

    252 publications

    16K citations

  6. Kyoto University

    Kyoto, Japan

    38 h-index

    287 publications

    19.4K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    31 h-index

    140 publications

    86.3K citations

  8. Center for Cancer Research

    Bethesda, United States

    31 h-index

    169 publications

    11.8K citations

1–8 of 2.3K

Venues

  1. Journal of Biological Chemistry

    JBC · 262 publications · 17.4K citations

    72

    h-index

  2. Nucleic Acids Research

    317 publications · 16K citations

    66

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 141 publications · 16.9K citations

    66

    h-index

  4. Biochemistry

    196 publications · 10.4K citations

    59

    h-index

  5. Journal of the American Chemical Society

    JACS · 121 publications · 10.3K citations

    56

    h-index

1–5