Concepedia

Apoptosome Formation

Apoptosome Formation is the molecular assembly process in which cytochrome c, released from mitochondria, binds to Apaf-1 in the presence of dATP or ATP, triggering oligomerization into a heptameric platform that recruits and activates procaspase-9 to initiate the intrinsic pathway of apoptosis.

275

Publications

27.4K

Citations

1.4K

Authors

458

Institutions

Publications per year

2017–2026

36

Parents

Children

Publications

275

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

Hua Zou, Yuchen Li, Xuesong Liu et al. · Journal of Biological Chemistry · 1999 · 2.1K citations · Full text

, , +17

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

Helen M. Beere, Beni B. Wolf, Kelvin Cain et al. · Nature Cell Biology · 2000 · 1.5K citations

, , +16

Three-Dimensional Structure of the Apoptosome

Devrim Acehan, Xuejun Jiang, David Morgan et al. · Molecular Cell · 2002 · 895 citations · Full text

, , +12

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Corey Rogers, Dan A. Erkes, Alexandria Nardone et al. · Nature Communications · 2019 · 831 citations · Full text

, , +17

Negative regulation of the Apaf-1 apoptosome by Hsp70

Ayman Saleh, Srinivasa M. Srinivasula, Levent Balkir et al. · Nature Cell Biology · 2000 · 820 citations

, , +14

1–5 of 275

Authors

1.4K

  1. CW
    Christopher W. Akey

    Boston University, United States

    10 publications · 1.6K citations

    10

    h-index

  2. KC
    Kelvin Cain

    MRC Toxicology Unit, United Kingdom

    10 publications · 2.5K citations

    10

    h-index

  3. YS
    Yigong Shi

    Tsinghua University, China

    10 publications · 981 citations

    10

    h-index

  4. SB
    Shawn B. Bratton

    The University of Texas at Austin, United States

    10 publications · 1.3K citations

    10

    h-index

  5. HO
    Howard O. Fearnhead

    Ollscoil na Gaillimhe – University of Galway, Ireland

    9 publications · 435 citations

    9

    h-index

1–5 of 1.4K

Institutions

458

  1. The University of Texas Southwestern Medical Center

    Dallas, United States

    13 h-index

    37 publications

    15.5K citations

  2. University of Leicester

    Leicester, United Kingdom

    12 h-index

    53 publications

    10.8K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    26 publications

    12.9K citations

  4. Boston University

    Boston, United States

    10 h-index

    32 publications

    4.8K citations

  5. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    9 h-index

    37 publications

    4.5K citations

  6. Ollscoil na Gaillimhe – University of Galway

    Galway, Ireland

    9 h-index

    30 publications

    1.6K citations

  7. Tsinghua University

    Beijing, China

    8 h-index

    50 publications

    5.4K citations

  8. University of Rome Tor Vergata

    Rome, Italy

    7 h-index

    21 publications

    1.7K citations

1–8 of 458

Venues

  1. Journal of Biological Chemistry

    JBC · 39 publications · 6.7K citations

    33

    h-index

  2. PubMed

    Repository · 10 publications · 316 citations

    10

    h-index

  3. Cell Death and Differentiation

    CDD · 9 publications · 867 citations

    9

    h-index

  4. PLoS ONE

    8 publications · 286 citations

    8

    h-index

  5. Biochemistry

    7 publications · 284 citations

    7

    h-index

1–5