Concepedia

Dimerization Of Apaf-1

Dimerization of Apaf-1 is a molecular event in which two Apaf-1 monomers associate through their nucleotide-binding domains to form a symmetric dimer, serving as the initial oligomeric intermediate in apoptosome assembly during intrinsic apoptosis.

36

Publications

5.8K

Citations

146

Authors

58

Institutions

Publications per year

2017–2026

3

Parents

Publications

36

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

Hua Zou, Yuchen Li, Xuesong Liu et al. · Journal of Biological Chemistry · 1999 · 2.1K citations · Full text

, , +17

Caspase-9 and APAF-1 form an active holoenzyme

Joe Rodriguez, Yuri Lazebnik · Genes & Development · 1999 · 564 citations · Full text

, , +11

Cytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation

Ayman Saleh, Srinivasa M. Srinivasula, Samir Acharya et al. · Journal of Biological Chemistry · 1999 · 503 citations · Full text

, , +16

Dimer formation drives the activation of the cell death protease caspase 9

Martin Renatus, Henning R. Stennicke, Fiona L. Scott et al. · Proceedings of the National Academy of Sciences · 2001 · 446 citations · Full text

, , +17

Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes

Kelvin Cain, Shawn B. Bratton, Claudia Langlais et al. · Journal of Biological Chemistry · 2000 · 315 citations · Full text

, , +16

1–5 of 36

Authors

146

  1. KC
    Kelvin Cain

    MRC Toxicology Unit, United Kingdom

    4 publications · 617 citations

    4

    h-index

  2. SB
    Shawn B. Bratton

    The University of Texas at Austin, United States

    3 publications · 447 citations

    3

    h-index

  3. MW
    M. Wisniewska

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Poland

    3 publications · 262 citations

    3

    h-index

  4. DG
    David G. Brown

    Pfizer (United Kingdom), United Kingdom

    3 publications · 569 citations

    3

    h-index

  5. GM
    Gerald M. Cohen

    University of Leicester, United Kingdom

    3 publications · 557 citations

    3

    h-index

1–5 of 146

Institutions

58

  1. MRC Toxicology Unit

    Cambridge, United Kingdom

    4 h-index

    14 publications

    1.7K citations

  2. University of Leicester

    Leicester, United Kingdom

    4 h-index

    20 publications

    3.6K citations

  3. The University of Texas Southwestern Medical Center

    Dallas, United States

    3 h-index

    13 publications

    8.9K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    12 publications

    6.8K citations

  5. Institut Pasteur

    Paris, France

    2 h-index

    7 publications

    794 citations

  6. Tsinghua University

    Beijing, China

    2 h-index

    10 publications

    1K citations

  7. Sidney Kimmel Cancer Center

    Philadelphia, United States

    2 h-index

    7 publications

    2.7K citations

  8. Research Institute of Molecular Pathology

    Vienna, Austria

    2 h-index

    4 publications

    502 citations

1–8 of 58

Venues

  1. Journal of Biological Chemistry

    JBC · 9 publications · 3.4K citations

    9

    h-index

  2. PubMed

    Repository · 3 publications · 296 citations

    3

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 557 citations

    2

    h-index

  4. Molecular and Cellular Biology

    MCB · 2 publications · 227 citations

    2

    h-index

  5. Oncogene

    2 publications · 68 citations

    2

    h-index

1–5