Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

Xu Luo, I. Imawati Budihardjo, Hua Zou, +2

Cell

MitophagySignal TransductionBiochemistryMitochondrial FunctionCell Signaling +8

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

Hua Zou, William J. Henzel, Xuesong Liu, +2

Cell

Signal TransductionSignaling PathwayMolecular PathwayMolecular RegulationMedicine +10

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

Hua Zou, Yuchen Li, Xuesong Liu, +1

Journal of Biological Chemistry

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

Xuesong Liu, Hua Zou, Clive A. Slaughter, +1

Cell

Functions DownstreamSignaling PathwayCell RegulationApoptosisCell Death +6

Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase

Clifford D. Mol, Douglas R. Dougan, T. Schneider, +7

Journal of Biological Chemistry

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

Xuesong Liu, Peng Li, Hua Zou, +3

Proceedings of the National Academy of Sciences

Dna DamageApoptosisMolecular BiologyCell DeathCell Cycle +15

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Kathleen Aertgeerts, R.J. Skene, Jason K. Yano, +12

Journal of Biological Chemistry

Crystal StructureMolecular BiologyCancer BiologyTumor BiologyHer2 Protein +20

An IAP-IAP Complex Inhibits Apoptosis

Takehiko Dohi, Kazuya Okada, Fang Xia, +10

Journal of Biological Chemistry

Signal TransductionSignaling PathwayApoptosisImmunologyCell Death +10

Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Thorsten Oost, Chaohong Sun, Robert C. Armstrong, +14

Journal of Medicinal Chemistry

ImmunologyCell DeathAntiapoptotic Protein XiapPharmacotherapyImmunotherapy +16

Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway

Antony Rodriguez, Hua Zou, Po Chen, +2

Nature Cell Biology

Developmental BiologyMedicineGeneticsApoptosisCell Death +5