Punit P. Seth - Concepedia

Author

Punit P. Seth

Ionis Pharmaceuticals (United States)ORCID

Also Known As

P. P. SETH, P. P. Seth, P.P. Seth, Punit P Seth, Punit P. Seth, Punit Seth, Punit P Seth, Punit P. Seth, Seth, P. P., Seth, P.P.

164

Publications

8.2K

Citations

H-Index

107

Concepts

All Affiliations

Ionis Pharmaceuticals (United States)Université de Montréal University of British Columbia Vanderbilt University

About

Punit P. Seth is an author at Ionis Pharmaceuticals (United States) specializing in medicine, natural sciences, and biochemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	23	36	2.3K
2	Natural Sciences	23	34	2.6K
3	Biochemistry	22	31	2.1K
4	Engineering	11	11	581
5	Allergy	2	2	233

Punit P. Seth

105

Publications

7.3K

Citations

H-Index

Page 1

	Year	Citations
Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice Thazha P. Prakash, Mark J. Graham, Jinghua Yu, Nucleic Acids Research	2014	579
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa, Nature Biotechnology Protein FunctionSignal TransductionBiochemistryG Protein-coupled ReceptorNatural Sciences	2019	308
Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals Punit P. Seth, Andrew Siwkowski, Charles Allerson, Journal of Medicinal Chemistry	2008	263
Single-Stranded siRNAs Activate RNAi in Animals Walt F. Lima, Thazha P. Prakash, Heather Murray, Cell Natural SciencesRna BiologyMolecular BiologySmall RnaGene Expression	2012	254
Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′<i>O</i>-Methoxyethyl and 2′,4′-Constrained 2′<i>O</i>-Ethyl Nucleic Acid Analogues Punit P. Seth, Guillermo Vasquez, Charles A. Allerson, The Journal of Organic Chemistry Bioorganic ChemistryEngineering2',4'-Constrained MoeMolecular BiologyOrganic Chemistry	2010	208
Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts Sebastien A. Burel, Christopher E. Hart, Patrick Cauntay, Nucleic Acids Research ImmunologyMolecular BiologyLong Pre-mrna TranscriptsHigh Affinity ModificationsToxic Lna Asos	2015	191
Targeted delivery of antisense oligonucleotides to pancreatic β-cells Carina Ämmälä, William J. Drury, Laurent Knerr, Science Advances	2018	177
SAR by MS: Discovery of a New Class of RNA-Binding Small Molecules for the Hepatitis C Virus: Internal Ribosome Entry Site IIA Subdomain Punit P. Seth, Alycia Miyaji, Elizabeth A. Jefferson, Journal of Medicinal Chemistry	2005	172
Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver Colton M. Miller, Aaron J. Donner, Emma E Blank, Nucleic Acids Research Molecular BiologyInternalization RatesStabilin ClassMolecular PharmacologyEndocytic Pathway	2016	162
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS Michael E. Østergaard, Amber L. Southwell, Holly Kordasiewicz, Nucleic Acids Research	2013	158

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