Punit P. Seth

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice

Thazha P. Prakash, Mark J. Graham, Jinghua Yu et al. · Nucleic Acids Research · 2014 · 597 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +17

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa et al. · Nature Biotechnology · 2019 · 333 citations

Medicine, Biochemistry, Pharmacology +13

Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

Punit P. Seth, Andrew Siwkowski, Charles Allerson et al. · Journal of Medicinal Chemistry · 2008 · 267 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +17

Single-Stranded siRNAs Activate RNAi in Animals

Walt F. Lima, Thazha P. Prakash, Heather Murray et al. · Cell · 2012 · 257 citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′<i>O</i>-Methoxyethyl and 2′,4′-Constrained 2′<i>O</i>-Ethyl Nucleic Acid Analogues

Punit P. Seth, Guillermo Vasquez, Charles A. Allerson et al. · The Journal of Organic Chemistry · 2010 · 211 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +17