Wen Shen

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa et al. · Nature Biotechnology · 2019 · 308 citations

Protein Function, Signal Transduction, Biochemistry +13

Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages

Xue‐hai Liang, Hong Sun, Wen Shen et al. · Nucleic Acids Research · 2015 · 176 citations · Full text

Protein Assembly, Molecular Biology, Protein Folding +19

Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels

Xue‐hai Liang, Hong Sun, Wen Shen et al. · Nucleic Acids Research · 2017 · 129 citations · Full text

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Michael T. Migawa, Wen Shen, Wei Wan et al. · Nucleic Acids Research · 2019 · 119 citations · Full text

Signal Transduction, Biochemistry, Site-specific Replacement +11

2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF

Wen Shen, Xue‐hai Liang, Hong Sun et al. · Nucleic Acids Research · 2015 · 103 citations · Full text

Chemical Biology, 2′-Fluoro-modified Phosphorothioate Oligonucleotide, Nucleic Acid Chemistry +11