Wen Shen

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa et al. · Nature Biotechnology · 2019 · 333 citations

Medicine, Biochemistry, Pharmacology +13

Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages

Xue‐hai Liang, Hong Sun, Wen Shen et al. · Nucleic Acids Research · 2015 · 178 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels

Xue‐hai Liang, Hong Sun, Wen Shen et al. · Nucleic Acids Research · 2017 · 137 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Michael T. Migawa, Wen Shen, Guillermo Vasquez et al. · Nucleic Acids Research · 2019 · 124 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

Wen Shen, Cheryl Li De Hoyos, Hong Sun et al. · Nucleic Acids Research · 2018 · 109 citations · Full text

Pharmacy, Molecular Biology, Toxicology +13