Guillermo Vasquez

Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

Punit P. Seth, Andrew Siwkowski, Charles Allerson et al. · Journal of Medicinal Chemistry · 2008 · 267 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +17

Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′<i>O</i>-Methoxyethyl and 2′,4′-Constrained 2′<i>O</i>-Ethyl Nucleic Acid Analogues

Punit P. Seth, Guillermo Vasquez, Charles A. Allerson et al. · The Journal of Organic Chemistry · 2010 · 211 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +17

Comprehensive Structure–Activity Relationship of Triantennary<i>N</i>-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

Thazha P. Prakash, Jinghua Yu, Michael T. Migawa et al. · Journal of Medicinal Chemistry · 2016 · 131 citations

Pharmacy, Pharmaceutics, Pharmacology +12

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

Michael T. Migawa, Guillermo Vasquez, Heather Murray et al. · Nucleic Acids Research · 2014 · 129 citations · Full text

Pharmacy, Biochemistry, Chemistry +16

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Michael T. Migawa, Wen Shen, Guillermo Vasquez et al. · Nucleic Acids Research · 2019 · 124 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14