Thazha P. Prakash

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice

Thazha P. Prakash, Mark J. Graham, Jinghua Yu et al. · Nucleic Acids Research · 2014 · 579 citations · Full text

Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA

Charles Allerson, Namir Sioufi, Russell Jarres et al. · Journal of Medicinal Chemistry · 2005 · 440 citations

Vitro Potency, Stability Compared, Small Interfering Rna +13

Positional Effect of Chemical Modifications on Short Interference RNA Activity in Mammalian Cells

Thazha P. Prakash, Charles Allerson, Prasad Dande et al. · Journal of Medicinal Chemistry · 2005 · 280 citations

Molecular Biology, Sense Strand, Long Non-coding Rna +18

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

Dongbo Yu, Hannah M. Pendergraff, Jing Liu et al. · Cell · 2012 · 275 citations · Full text

Natural Sciences, Genetics, Rna Biology +6

Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

Punit P. Seth, Andrew Siwkowski, Charles Allerson et al. · Journal of Medicinal Chemistry · 2008 · 263 citations · Full text