Mark J. Graham

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

Christine Esau, Scott Davis, Susan Murray et al. · Cell Metabolism · 2006 · 2.1K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +16

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

Brian J. Bennett, Thomas Q. de Aguiar Vallim, Zeneng Wang et al. · Cell Metabolism · 2013 · 1.1K citations · Full text

Life Sciences, Genetics, Pharmacology +14

Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials

Nicholas J. Viney, Julian C. van Capelleveen, Richard S. Geary et al. · The Lancet · 2016 · 748 citations

Medicine, Pharmacology, Clinical Pharmacology +6

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice

Thazha P. Prakash, Mark J. Graham, Jinghua Yu et al. · Nucleic Acids Research · 2014 · 597 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +17

Cardiovascular and Metabolic Effects of <i>ANGPTL3</i> Antisense Oligonucleotides

Mark J. Graham, Richard Lee, Teresa Brandt et al. · New England Journal of Medicine · 2017 · 581 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +14