Cheryl Li De Hoyos

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa et al. · Nature Biotechnology · 2019 · 333 citations

Medicine, Biochemistry, Pharmacology +13

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Michael T. Migawa, Wen Shen, Guillermo Vasquez et al. · Nucleic Acids Research · 2019 · 124 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

Wen Shen, Cheryl Li De Hoyos, Hong Sun et al. · Nucleic Acids Research · 2018 · 109 citations · Full text

Pharmacy, Molecular Biology, Toxicology +13

Viable<i>RNaseH1</i>knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

Walt F. Lima, Heather Murray, Sagar Damle et al. · Nucleic Acids Research · 2016 · 105 citations · Full text

Life Sciences, Genetics, Molecular Biology +12

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides

Michael E. Østergaard, Cheryl Li De Hoyos, Wen Shen et al. · Nucleic Acids Research · 2020 · 100 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17