Cheryl Li De Hoyos - Concepedia

Concepedia

Author

Cheryl Li De Hoyos

Ionis Pharmaceuticals (United States)

Also Known As

Cheryl L De Hoyos, Cheryl L. De Hoyos, Cheryl L. De Hoyos, Cheryl Li De Hoyos, Cheryl Li De Hoyos

15

Publications

1.1K

Citations

14

H-Index

40

Concepts

All Affiliations

Ionis Pharmaceuticals (United States)

CL

About

Cheryl Li De Hoyos is an author at Ionis Pharmaceuticals (United States) specializing in natural sciences, medicine, and molecular biology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	9	9	757
2	Natural Sciences	9	9	844
3	Biochemistry	5	5	649
4	Biomolecular Engineering	2	2	83
5	Engineering	1	1	32

Cheryl Li De Hoyos

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15

Publications

1.1K

Citations

14

H-Index

	Year	Citations
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa, Nature Biotechnology Protein FunctionSignal TransductionBiochemistryG Protein-coupled ReceptorNatural Sciences	2019	308
Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins Michael T. Migawa, Wen Shen, Wei Wan, Nucleic Acids Research Signal TransductionBiochemistrySite-specific ReplacementNatural SciencesOligonucleotide	2019	119
Viable<i>RNaseH1</i>knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function Walt F. Lima, Heather Murray, Sagar Damle, Nucleic Acids Research Mitochondrial DysfunctionRnase H1Molecular BiologyCell DeathLiver Function	2016	104
Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins Wen Shen, Cheryl Li De Hoyos, Hong Sun, Nucleic Acids Research ApoptosisMolecular BiologyCell DeathOxidative StressLiver Necrosis	2018	103
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides Michael E. Østergaard, Cheryl Li De Hoyos, Wei Wan, Nucleic Acids Research	2020	94
Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops Wen‐Hui Shen, Hong Sun, Cheryl Li De Hoyos, Nucleic Acids Research Rnase H1Molecular BiologyMammalian Rnase H1Transcriptional RegulationRna Binding Proteins	2017	68
RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery Walt F. Lima, Cheryl Li De Hoyos, Xue‐hai Liang, Nucleic Acids Research Rna Surveillance MachineryMolecular BiologyRna Cleavage ProductsRna SurveillanceLong Non-coding Rna	2016	67
Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes Xue‐hai Liang, Hong Sun, Chih‐Wei Hsu, Nucleic Acids Research Gcc2 ActionProtein SecretionM6pr Facilitates ReleaseMolecular BiologyPs Modifications	2019	44
Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs Guillermo Vasquez, Graeme C. Freestone, Wei Wan, Nucleic Acids Research	2021	44
Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation Wen Shen, Xue‐hai Liang, Hong Sun, PLoS ONE EngineeringMolecular BiologyC-myc ProteinNeat1 LncrnaCellular Physiology	2017	32

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