Cheryl Li De Hoyos

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa et al. · Nature Biotechnology · 2019 · 308 citations

Protein Function, Signal Transduction, Biochemistry +13

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Michael T. Migawa, Wen Shen, Wei Wan et al. · Nucleic Acids Research · 2019 · 119 citations · Full text

Signal Transduction, Biochemistry, Site-specific Replacement +11

Viable<i>RNaseH1</i>knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

Walt F. Lima, Heather Murray, Sagar Damle et al. · Nucleic Acids Research · 2016 · 104 citations · Full text

Mitochondrial Dysfunction, Rnase H1, Molecular Biology +18

Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

Wen Shen, Cheryl Li De Hoyos, Hong Sun et al. · Nucleic Acids Research · 2018 · 103 citations · Full text

Apoptosis, Molecular Biology, Cell Death +19

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides

Michael E. Østergaard, Cheryl Li De Hoyos, Wei Wan et al. · Nucleic Acids Research · 2020 · 94 citations · Full text