Xue‐hai Liang

Phosphorothioate modified oligonucleotide–protein interactions

Stanley T. Crooke, Timothy A. Vickers, Xue‐hai Liang · Nucleic Acids Research · 2020 · 318 citations · Full text

Nucleic Acid Chemistry, Biochemistry, Aso Chemical Modifications +13

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa et al. · Nature Biotechnology · 2019 · 308 citations

Protein Function, Signal Transduction, Biochemistry +13

RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

Xue‐hai Liang, Hong Sun, Joshua G Nichols et al. · Molecular Therapy · 2017 · 268 citations · Full text

Loss of rRNA modifications in the decoding center of the ribosome impairs translation and strongly delays pre-rRNA processing

Xue‐hai Liang, Qing Liu, Maurille J. Fournier · RNA · 2009 · 235 citations · Full text

rRNA Modifications in an Intersubunit Bridge of the Ribosome Strongly Affect Both Ribosome Biogenesis and Activity

Xue‐hai Liang, Qing Liu, Maurille J. Fournier · Molecular Cell · 2007 · 220 citations · Full text

Intersubunit Bridge, Systems Biology, Engineering +8