Joshua G Nichols

RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

Xue‐hai Liang, Hong Sun, Joshua G Nichols et al. · Molecular Therapy · 2017 · 268 citations · Full text

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Michael T. Migawa, Wen Shen, Wei Wan et al. · Nucleic Acids Research · 2019 · 119 citations · Full text

Signal Transduction, Biochemistry, Site-specific Replacement +11

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2′-modifications and enhances antisense activity

Xue‐hai Liang, Wen Shen, Hong Sun et al. · Nucleic Acids Research · 2016 · 78 citations · Full text

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

Xue‐hai Liang, Joshua G Nichols, Chih‐Wei Hsu et al. · Nucleic Acids Research · 2019 · 55 citations · Full text

Mrna Levels, Chemical Modification, Molecular Biology +16

Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

Xue‐hai Liang, Hong Sun, Chih‐Wei Hsu et al. · Nucleic Acids Research · 2019 · 44 citations · Full text

Gcc2 Action, Protein Secretion, M6pr Facilitates Release +16