Valeria R. Fantin

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Bryson D. Bennett et al. · Nature · 2009 · 4.1K citations · Full text

Medicine, Genetics, Molecular Genetics +10

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

María E. Figueroa, Omar Abdel‐Wahab, Chao Lü et al. · Cancer Cell · 2010 · 2.7K citations · Full text

Medicine, Genetics, Hematology +17

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Patrick S. Ward, Jay Patel, David R. Wise et al. · Cancer Cell · 2010 · 2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Valeria R. Fantin, Julie St‐Pierre, Philip Leder · Cancer Cell · 2006 · 1.6K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

Rob A. Cairns, Mark D. Minden, Edward M. Driggers et al. · The Journal of Experimental Medicine · 2010 · 727 citations · Full text

Life Sciences, Biochemistry, Oncology +17