John W. Ellingboe

Biochemical, Cellular, and <i>In vivo</i> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral‐Barza, Celine Shi et al. · Cancer Research · 2009 · 326 citations

Chemoprevention Strategy, Cellular Pharmacology, Selective Inhibitors +22

Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Scott C. Mayer, Anthony F. Kreft, Boyd L. Harrison et al. · Journal of Medicinal Chemistry · 2008 · 109 citations · Full text

Stable Analogue 10, Alzheimer ’, Social Sciences +19

Discovery of 5-Arylsulfonamido-3- (pyrrolidin-2-ylmethyl)-1<i>H</i>-indole Derivatives as Potent, Selective 5-HT₆Receptor Agonists and Antagonists

Derek C. Cole, William J. Lennox, Sabrina Lombardi et al. · Journal of Medicinal Chemistry · 2004 · 102 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Moderate Antagonist Activity +13

Acylguanidines as Small-Molecule β-Secretase Inhibitors

Derek C. Cole, Eric S. Manas, Joseph R. Stock et al. · Journal of Medicinal Chemistry · 2006 · 100 citations · Full text

Protein Assembly, Molecular Biology, Amyloid Precursor Protein +20

Discovery of Pyrano[3,4-<i>b</i>]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

Ariamala Gopalsamy, Kitae Lim, Gregory Ciszewski et al. · Journal of Medicinal Chemistry · 2004 · 96 citations · Full text

Replicon System, Novel Series, Biochemistry +12