Biochemical, Cellular, and <i>In vivo</i> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral‐Barza, Celine Shi, +15

Cancer Research

Chemoprevention StrategyCellular PharmacologySelective InhibitorsMtor SelectivityChemical Biology +20

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral‐Barza, +17

Cancer Research

Antitumor ActivityChemoprevention StrategyPharmacotherapyCancer BiologyTumor Biology +20

Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells

Boris Shor, Jiang Wu, Quazi Shakey, +4

Journal of Biological Chemistry

Tumor BiologyTranscriptional RegulationSignaling PathwayCell RegulationMedicine +11

Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes

Maria Nunes, Celine Shi, Lee M. Greenberger

Molecular Cancer Therapeutics

Normal Human KeratinocytesTyrosine KinaseAbstract Ekb-569DermatologyTumor Biology +17

Prolonged Circulating Lives of Single-Chain Fv Proteins Conjugated with Polyethylene Glycol:  A Comparison of Conjugation Chemistries and Compounds

L. Stanford Lee, Charles Conover, Celine Shi, +2

Bioconjugate Chemistry

Response and determinants of cancer cell susceptibility to PI3K inhibitors: Combined targeting of PI3K and Mek1 as an effective anticancer strategy

Ker Yu, Lourdes Toral‐Barza, Celine Shi, +2

Cancer Biology & Therapy

Small Molecule InhibitorsPi3k InhibitorsChemoprevention StrategyCell DeathTumor Biology +14

Drug Delivery Systems Employing 1,6-Elimination:  Releasable Poly(ethylene glycol) Conjugates of Proteins

Stanford Lee, Richard B. Greenwald, Jeffrey M. McGuire, +2

Bioconjugate Chemistry

Ethylene GlycolMolecular BiologyProtein RefoldingEnzymatic ModificationProtein Purification +21

Reciprocal regulation of amino acid import and epigenetic state through Lat1 and <scp>EZH</scp> 2

Stephen G. Dann, Michael Ryskin, Anthony M. Barsotti, +15

The EMBO Journal

Molecular RegulationEpigenetic ChangeGeneticsMolecular BiologyEpigenetics +14

mTOR complex-2 stimulates acetyl-CoA and <i>de novo</i> lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer

Yaqing Chen, Jianchang Qian, Qun He, +6

Oncotarget

Mtor Complex-2 StimulatesBreast OncologyMetabolic RemodelingCancer BiologyBreast Cancer Metabolism +20

Two Photoaffinity Analogues of the Tripeptide, Hemiasterlin, Exclusively Label α-Tubulin

Maria Nunes, Joshua A. Kaplan, Joseph L. Wooters, +12

Biochemistry

Bioorganic ChemistryPurified TubulinChemical BiologyTripeptide HemiasterlinPharmaceutical Chemistry +16