Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

Ker Yu, William Bayona, Caleb B. Kallen, +5

Journal of Biological Chemistry

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.

Ker Yu, Lourdes Toral‐Barza, Carolyn Discafani, +4

Endocrine Related Cancer

Breast OncologyCell CycleCancer BiologyTumor BiologySensitive Lines +14

Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

Christina H. Eng, Ker Yu, Judy Lucas, +2

Science Signaling

Biochemical, Cellular, and <i>In vivo</i> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral‐Barza, Celine Shi, +15

Cancer Research

Chemoprevention StrategyCellular PharmacologySelective InhibitorsMtor SelectivityChemical Biology +20

Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound <b>26</b> (PKI-587), a Highly Efficacious Dual Inhibitor

Aranapakam M. Venkatesan, Christoph M. Dehnhardt, Efren Delos Santos, +13

Journal of Medicinal Chemistry

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral‐Barza, +17

Cancer Research

Antitumor ActivityChemoprevention StrategyPharmacotherapyCancer BiologyTumor Biology +20

Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells

Boris Shor, Jiang Wu, Quazi Shakey, +4

Journal of Biological Chemistry

Tumor BiologyTranscriptional RegulationSignaling PathwayCell RegulationMedicine +11

A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis

Boris Shor, Weiguo Zhang, Lourdes Toral‐Barza, +4

Cancer Research

Chemoprevention StrategyGlobal Protein SynthesisCancer BiologyTumor BiologyProtein Synthesis +18

ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines

Arie Zask, Jeroen C. Verheijen, Kevin J. Curran, +16

Journal of Medicinal Chemistry

Chemical BiologyPharmaceutical ChemistryTumor BiologyMedicinal ChemistryMammalian Target +17

Morpholine Derivatives Greatly Enhance the Selectivity of Mammalian Target of Rapamycin (mTOR) Inhibitors

Arie Zask, Joshua A. Kaplan, Jeroen C. Verheijen, +8

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistryPharmacotherapyPharmaceutical ChemistryDrug Resistance +15