Efren Delos Santos

Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound <b>26</b> (PKI-587), a Highly Efficacious Dual Inhibitor

Aranapakam M. Venkatesan, Christoph M. Dehnhardt, Efren Delos Santos et al. · Journal of Medicinal Chemistry · 2010 · 212 citations · Full text

Medicine, Oncology, Pharmacology +14

Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor

Robert Mallon, Larry Feldberg, Judy Lucas et al. · Clinical Cancer Research · 2011 · 170 citations · Full text

Medicine, Oncology, Pharmacology +17

Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402

Christoph M. Dehnhardt, Aranapakam M. Venkatesan, Efren Delos Santos et al. · Journal of Medicinal Chemistry · 2009 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

PKI-179: An orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor

Aranapakam M. Venkatesan, Zecheng Chen, Osvaldo dos Santos et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 71 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +10

2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer

Zecheng Chen, Aranapakam M. Venkatesan, Christoph M. Dehnhardt et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 69 citations

Medicine, Medicinal Chemistry, Pharmacology +10