Aranapakam M. Venkatesan

Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound <b>26</b> (PKI-587), a Highly Efficacious Dual Inhibitor

Aranapakam M. Venkatesan, Christoph M. Dehnhardt, Efren Delos Santos et al. · Journal of Medicinal Chemistry · 2010 · 212 citations · Full text

Medicine, Oncology, Pharmacology +14

Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor

Robert Mallon, Larry Feldberg, Judy Lucas et al. · Clinical Cancer Research · 2011 · 170 citations · Full text

Medicine, Oncology, Pharmacology +17

5-Fluoro-2-methyl-<i>N</i>-[4-(5<i>H</i>-pyrrolo[2,1-<i>c</i>]- [1,4]benzodiazepin-10(11<i>H</i>)-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985):  An Orally Active Arginine Vasopressin Antagonist with Selectivity for V₂Receptors

J. Donald Albright, Marvin F. Reich, Efren G. Delos Santos et al. · Journal of Medicinal Chemistry · 1998 · 149 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors:  Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates

Aranapakam M. Venkatesan, Yansong Gu, Osvaldo dos Santos et al. · Journal of Medicinal Chemistry · 2004 · 79 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +16

Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402

Christoph M. Dehnhardt, Aranapakam M. Venkatesan, Efren Delos Santos et al. · Journal of Medicinal Chemistry · 2009 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16