Zecheng Chen

Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound <b>26</b> (PKI-587), a Highly Efficacious Dual Inhibitor

Aranapakam M. Venkatesan, Christoph M. Dehnhardt, Efren Delos Santos et al. · Journal of Medicinal Chemistry · 2010 · 212 citations · Full text

Medicine, Oncology, Pharmacology +14

Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor

Robert Mallon, Larry Feldberg, Judy Lucas et al. · Clinical Cancer Research · 2011 · 170 citations · Full text

Medicine, Oncology, Pharmacology +17

Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications

Andreas Maderna, Matthew Doroski, Chakrapani Subramanyam et al. · Journal of Medicinal Chemistry · 2014 · 132 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

The concentration of erlotinib in the cerebrospinal fluid of patients with brain metastasis from non-small-cell lung cancer

Yanming Deng, Weineng Feng, Jing Wu et al. · Molecular and Clinical Oncology · 2013 · 96 citations · Full text

Medicine, Oncology, Pharmacology +15

Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402

Christoph M. Dehnhardt, Aranapakam M. Venkatesan, Efren Delos Santos et al. · Journal of Medicinal Chemistry · 2009 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16