Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments

Frank Loganzo, Xingzhi Tan, Matthew Sung, +19

Molecular Cancer Therapeutics

Breast OncologyImmunologyAdc ResistanceImmunoeditingImmunotherapeutics +14

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

Cory Iverson, Gary Larson, Chon Lai, +10

Cancer Research

Chemoprevention StrategyCell ProliferationTumor BiologyOncologyReceptor Tyrosine Kinase +18

Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications

Andreas Maderna, Matthew Doroski, Chakrapani Subramanyam, +18

Journal of Medicinal Chemistry

NanotherapeuticsLead AuristatinPeptide ScienceChemical BiologyPharmaceutical Chemistry +18

A Camouflagednido-Carborane Anion: Facile Synthesis of Octa-B-methyl-1,2-dicarba-closo-dodecaborane(12) and Its Deboration Reaction

Axel Herzog, Andreas Maderna, George N. Harakas, +2

Chemistry - A European Journal

Enantioselective SynthesisBioorganic ChemistryOrtho-carborane YieldsEngineeringHeterocyclic +13

Synthesis, Molecular Editing, and Biological Assessment of the Potent Cytotoxin Leiodermatolide

Damien Mailhol, Jens Willwacher, Nina Kausch‐Busies, +8

Journal of the American Chemical Society

CytoskeletonChemical BiologyPotent Cytotoxin LeiodermatolidePharmaceutical ChemistryTumor Biology +21

Total Syntheses and Biological Reassessment of Lactimidomycin, Isomigrastatin and Congener Glutarimide Antibiotics

Kévin Micoine, Peter Persich, Josep Llaveria, +4

Chemistry - A European Journal

Bioorganic ChemistryEngineeringTotal SynthesesTumor BiologyBiological Reassessment +20

Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis

Kyung‐Hee Kim, Andreas Maderna, Mark E. Schnute, +17

Bioorganic & Medicinal Chemistry Letters

Rheumatoid DisorderRheumatologyMedicinal ChemistryAnti-inflammatoryMedicine +8

Syntheses, Structures, and Reactivity of Hexaborylbenzene Derivatives

Christian Ester, Andreas Maderna, Hans Pritzkow, +1

European Journal of Inorganic Chemistry

DerivativesOrganic ChemistryChemistryHexaborylbenzene DerivativesDerivative (Chemistry) +1

Hexaborylbenzene and Tetraborylethene Derivatives

Andreas Maderna, Hans Pritzkow, Walter Siebert

Angewandte Chemie International Edition in English

Chemical EngineeringDerivative (Chemistry)DerivativesEngineeringDiborane 3 +8

Twelvefold Functionalization of an Icosahedral Surface by Total Esterification of [B12(OH)12]2−: 12(12)-Closomers

Andreas Maderna, Carolyn B. Knobler, M. Frederick Hawthorne

Angewandte Chemie International Edition