Ariamala Gopalsamy

Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

Erik C. Hett, Hua Xu, Kieran F. Geoghegan et al. · ACS Chemical Biology · 2015 · 191 citations

Molecular Pharmacology, Drug Target, Biochemistry +15

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold et al. · Journal of Medicinal Chemistry · 2018 · 165 citations · Full text

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue

Olugbeminiyi Fadeyi, Lise R. Hoth, Chulho Choi et al. · ACS Chemical Biology · 2017 · 134 citations

Drug Target, Bioorganic Chemistry, Molecular Biology +22

A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation

Peter V.N. Bodine, Barbara Stauffer, Helga Ponce‐de‐Leon et al. · Bone · 2009 · 124 citations

Sclerostin, Signal Transduction, Bone Morphogenic Protein +12

Discovery of Pyrano[3,4-<i>b</i>]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

Ariamala Gopalsamy, Kitae Lim, Gregory Ciszewski et al. · Journal of Medicinal Chemistry · 2004 · 96 citations · Full text

Replicon System, Novel Series, Biochemistry +12