Patrick M. Eidam

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong et al. · Journal of Medicinal Chemistry · 2017 · 464 citations · Full text

Drug Target, Immunology, Cell Death +22

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

Philip A. Harris, Jill M. Marinis, John D. Lich et al. · ACS Medicinal Chemistry Letters · 2019 · 79 citations · Full text

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase

Philip A. Harris, Nicolas Faucher, Nicolas George et al. · Journal of Medicinal Chemistry · 2019 · 68 citations · Full text

Drug Target, Immunology, Efficacious Inhibitors +19

Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway

David J. Rickard, Clark A. Sehon, Viera Kasparcova et al. · PLoS ONE · 2013 · 55 citations · Full text

Drug Target, Innate Immune System, Immunology +21

Diastereoselective Additions of Chiral Vinylzinc Reagents to α-Chiral Aldehydes

James A. Marshall, Patrick M. Eidam · Organic Letters · 2004 · 43 citations