Clark A. Sehon

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

William J. Kaiser, Haripriya Sridharan, Chunzi Huang et al. · Journal of Biological Chemistry · 2013 · 912 citations · Full text

Apoptosis, Immunology, Immune Regulation +23

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

Yves Dondelinger, Wim Declercq, Sylvie Montessuit et al. · Cell Reports · 2014 · 797 citations · Full text

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

Pratyusha Mandal, Scott B. Berger, Sirika Pillay et al. · Molecular Cell · 2014 · 593 citations · Full text

Cell Regulation, Pronecrotic Kinase Activity, Receptor Tyrosine Kinase +6

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong et al. · Journal of Medicinal Chemistry · 2017 · 464 citations · Full text

Drug Target, Immunology, Cell Death +22

Total Syntheses of Ningalin A, Lamellarin O, Lukianol A, and Permethyl Storniamide A Utilizing Heterocyclic Azadiene Diels−Alder Reactions

Dale L. Boger, Christopher W. Boyce, Marc Labroli et al. · Journal of the American Chemical Society · 1998 · 381 citations

Bioorganic Chemistry, Engineering, Chemoprevention Strategy +21