John Cantwell

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang et al. · Proceedings of the National Academy of Sciences · 2008 · 1.3K citations · Full text

Medicine, Oncology, Pharmacology +15

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel et al. · Nature Cell Biology · 2014 · 740 citations

Life Sciences, Biochemistry, Cell Biology +16

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

Julien P. N. Papillon, Katsumasa Nakajima, Christopher D. Adair et al. · Journal of Medicinal Chemistry · 2018 · 237 citations · Full text

Medicine, Cancer Biology, Oncology +11

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

Dean R. Artis, Jack J. Lin, Chao Zhang et al. · Proceedings of the National Academy of Sciences · 2008 · 148 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase

Andreas Lingel, Martin Sendzik, Ying Huang et al. · Journal of Medicinal Chemistry · 2016 · 58 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17